Phototherapy Induced Thrombocytopenia –A Comparative Study among Breastfed Term And Preterm Neonates With Hyperbilirubinemia
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 4
Abstract
Introduction: There are reports which attribute phototherapy with acquired thrombocytopenia during early neonatal period. Present study is been planned to assess the difference in the phototherapy induced thrombocytopenia between breastfed preterm neonates and full term neonates with unconjugated hyperbilirubinaemia. Material and Methods: It is a tertiary care teaching hospital based prospective study over a period of 2 years. 25 breastfed full term neonates and 25 breastfed preterm neonates with unconjugated hyperbilirubinemia requiring phototherapy for at least 48 hours were selected for the study. Pathologic hyperbilirubinemia requiring phototherapy was defined as per 2004 American Academy of Pediatrics hyperbilirubinemia treatment guidelines. Platelet count and total serum bilirubin levels, before and after 48 hours of phototherapy were estimated. Results: After the phototherapy, term neonate showed statistically significant change in the platelet count (2.7 ± 0 .83lakhs/per ml,) when compared to pretreatment levels platelet count 2.0± 0.69(lakhs/per ml) (T=3.4 to 11.4, p=0.0001).After the phototherapy, it was observed that preterm neonates did not show a statistical difference in the platelet count between pretreatment and post treatment levels (T=1.55, p=0.125) . There was no association between the gestational age (term/preterm) and the incidence of thrombocytopenia (Chi square =0.035,p=0.85) as assessed by chi square test with Yates correction. Conclusion: Gestational age of neonate is not the factor associated with incidence of thrombocytopenia in children receiving phototherapy. Studies with larger sample size will give more definitive results on this issue.
Authors and Affiliations
Abdul Tawab C. N, Prakash R M Saldanha, Mithun . H. K
Keywords
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