Hypoglycemic Effect of Alcohol Extract of Eugenia Jambolana Seed Against Dexamethasone Induced Diabetes In Rats
Journal Title: International Journal of Medical and Health Sciences - Year 2015, Vol 4, Issue 1
Abstract
Objectives: The present study was planned to evaluate the hypoglycemic effect of alcohol extract of Eugenia jambolana (E.J) seed against Dexamethasone induced diabetes in Wistar rats. Materials and Methods: Rats were divided in to 9 groups. Group-I served as a control, Group-II: Dexamethasone (4mg/kg/i.p/6 days), Group-III: Metformin (500mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-IV: Metformin (1g/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-V: Rosiglitazone (8mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-VI: Rosiglitazone (16mg/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group- VII: Alcohol extract of E.J (3gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days), Group-VIII: Alcohol extract of E.J (6gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days) Group-IX: Alcohol extract of E.J (12gm/kg/orally/1-12 days) + Dexamethasone (4mg/kg/i.p/7-12 days). Standard drug and plant extract were administered their respective groups 1 to 6 days, from 7 to 12 days it was administered along with Dexamethasone (4mg/kg). On 12th day, after overnight fasting, a retro-orbital puncture was performed for obtaining blood samples to estimate the fasting blood glucose and insulin, and the same procedure was followed 30min, 60min and 120min after a glucose load of 2.5g/kg i.p for estimation of post glucose load blood glucose and insulin level. Results: Dexamethaosne group showed increased fasting and post glucose load the glucose and insulin levels when compared to normal control. Whereas E.J extract 12gm/kg group showed decreased glucose and insulin level compared to Dexamethasone group. Anti-hyperglycemic effect of E.J seed extract like as standard drugs. Conclusion: Prior administration of plant extract significantly prevents the Dexamethsone induced hyperglycemia in Wistar Albino rats.
Authors and Affiliations
Sarath Babu. K, Nagendra Nayak, Hebbal. G. V
Keywords
Related Articles
- EP ID EP39850
- DOI -
- Views 286
- Downloads 0
Clinicopathological Analysis of Benign tumours of the Sinonasal tract
Background: The nasal cavity and the paranasal sinuses form a single functional unit. Sino nasal tumours are characterized by low incidence, nonspecific symptoms, and late presentation. The sinonasal tumours encompass a...
Antioxidant activity of cissus quadrangularis on sodium perchlorate-induced oxidative damage in rats
The present study was carried out to evaluate the antioxidant activity of flavonoid rich fraction from Cissus quadrangularis(C.Q) Linn on sodium perchlorate induced oxidative stress in rats. Animals were divided into f...
Urological Manifestations of HIV infection and AIDS
Introduction: Global scenario of HIV infection has changed dramatically of late. The increasing availability of antiretroviral drugs has helped to combat HIV replication. Both viral load and CD4 T-cell count are reliab...
Levels of Circulatory Endothelial Progenitor Cells and Gamma Glutamyltransferase in Ghanaians with Cardiovascular Disease
Endothelial progenitor cells (EPCs) play a key role in the vascular pathology of stroke, congestive cardiac failure (CCF) and hypertension. Reduced numbers of circulating endothelial progenitor cells have been implicate...
Assessment of Eustachian tube function before and after cleft palate repair
Background: The incidence of hearing loss is higher in children with cleft lip and/or cleft palate. The etiologic basis for middle ear pathology and hearing loss in patients with Cleft palate is considered to be Eustach...