A STUDY OF SERUM HOMOCYSTEINE LEVEL IN PATIENTS WITH SUBCLINICAL HYPOTHYROIDISM
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 4
Abstract
BACKGROUND Subclinical hypothyroidism is defined as a persistent elevated serum Thyroid stimulating hormone (TSH) level with a normal serum thyroxine (FT4) concentration. This condition has evolved as a risk factor for many metabolic conditions and cardiovascular abnormalities. This study attempts to determine the relationship between subclinical hypothyroidism and homocysteine, which is recognised as an independent risk factor for accelerated atherosclerosis. Aims and Objectives- To evaluate the serum homocysteine level in patients with subclinical hypothyroidism and euthyroid healthy controls and to find out the correlation between serum homocysteine level and thyroid profile (if any). MATERIALS AND METHODS The study was conducted in a group of individuals consisting of 45 normal healthy subjects and 45 newly diagnosed cases of subclinical hypothyroidism attending Department of Endocrinology and Department of Medicine of Gauhati Medical College. Assessment of serum homocysteine was done by ELISA technique in Lisa Scan EM microplate ELISA reader, serum TSH and FT4 was estimated by VITROS 5600 Autoanalyzer. Statistical significance and correlation were assayed using independent “t” test and Pearson’s correlation test. Study Design- Descriptive comparative. RESULTS Analysis of data reveals that the mean Homocysteine level in case group was significantly higher than in control groups. A positive correlation was observed between TSH and Homocysteine levels in the case group and a negative correlation was observed between FT4 and Homocysteine level in the case group. CONCLUSION The present study shows that the patients with subclinical hypothyroidism have higher levels of Serum Homocysteine, which may be the cause of various cardiovascular complications involved with subclinical hypothyroidism.
Authors and Affiliations
Nithi Mahanta, Deepika Lahon, Barnali Bhattacharya Thakur
Keywords
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- EP ID EP285820
- DOI 10.14260/jemds/2018/101
- Views 117
- Downloads 0
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