A Study of Serum IgE Levels among Children of 6 Months to 5 Years of Age Group
Journal Title: International Journal of Contemporary Medical Research - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Sometimes the immune system reacts unnecessarily vigorously against otherwise harmless environmental agents, allergens. These over reactions are termed hypersensitivity reactions and fall into four subgroups, type’s I-IV, depending upon the mechanism behind the action. The type I hypersensitivity reactions are mediated by allergen specific IgE and are responsible for the clinical manifestation of atopic allergies, such as hay fever, food allergies, exzema, asthma and anaphylaxis, parasitic infections.Objective of the study was to study of serum IgE levels among children. Material and Methods: Ethical clearance was obtained from Kamineni Hospital Ethics Committee. This was a Hospital based prospective observational study. Approximately 99 children (OP and IP) 6 months to 5 years of age, visiting Kamineni Hospital, LB Nagar, Hyderabad with recurrent respiratory tract illnesses meeting defined inclusion and exclusion criteria were enrolled in the study after taking an informed consent and approval of institutional ethical committee. All patients were subjected to detailed questionnaire. A thorough clinical examination was done. Blood samples were collected and total serum IgE levels were determined. Results: Out of 99 children with RRTI studied, 48 had elevated serum IgE levels. Almost similar number of children with RRTI i.e. 51 had normal serum IgE levels. Serum IgE levels were significantly higher (66.07%) in males as compared to females (25.58%) with p value of 0.0003 (p < 0.05). The elevation of serum IgE levels was 48.48% in children (48 out of 99 children). It was noticed that, the number of children suffering from RRTI and the number of children with elevated serum IgE levels increased with increasing age. There was significant increase in serum IgE levels from 10% in infancy to 64.10% in 49-60th month with significant p value of 0.001. Conclusion: This study showed increasing number of children with recurrent respiratory tract illness and serum IgE levels with increasing age.
Authors and Affiliations
Sheetal Shantikumar Gandhi, K. Rajashekar Rao
Keywords
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