A study of serum levels of magnesium and C-Reactive Protein in Type 2 Diabetes Mellitus
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2017, Vol 4, Issue 3
Abstract
Type 2 Diabetes Mellitus (DM) has emerged as a major public health issue associated with various complications. Patients with metabolic syndrome (MS) have increased risk of developing cardiovascular disease and type 2 diabetes mellitus. C-reactive protein (CRP) correlates with individual components of metabolic syndrome and confer cardiovascular and metabolic risk. Magnesium is an essential ion involved in glucose homeostasis at multiple levels. Hypomagnesaemia has been reported in both IDDM and NIDDM patients. The present study is aimed to find the level of serum magnesium and CRP in type 2 diabetes mellitus and their association with development of metabolic syndrome and further development of type 2 diabetes mellitus. We have undertaken study on 120 subjects, categorized into three groups were involved in the study. FBS, lipid profile, serum magnesium and serum CRP levels were estimated in addition to recording of BP and anthropometric measurements. Results: Serum magnesium levels were towards lower limit of normal range in both T2DM and MS groups with respect to controls. Further, serum CRP levels were elevated to nearly two times in T2DM and MS groups. Conclusion: Our study findings suggest that serum magnesium and CRP levels are inversely related inflammatory markers are independent of Type 2 DM. This study could help in further studying degree of Hypomagnesemia and correlated elevation in CRP levels. Moreover, dietary supplementations of magnesium and/or other nutrient should be tried in case of Metabolic Syndrome along with assessment of Magnesium, CRP or other markers, in view to control these end stage pre diabetes condition from the development of Type 2 DM and to reduce the mortality resulting from cardiovascular diseases. Key Messages: Serum magnesium levels were significantly decreased in T2DM & Metabolic Syndrome. Serum CRP levels were significantly increased in T2DM & Metabolic Syndrome.
Authors and Affiliations
Rina Raibhan Wasnik, Veerabhadra Goud GK, DHSV Sarma, KP Joshi, Nagalakshmi CS
Keywords
Related Articles
- EP ID EP297383
- DOI 10.18231/2394-6377.2017.0072
- Views 50
- Downloads 0
Role of Glycemic control and Lipid profiles in management of Diabetic complications
Background & Objectives: Diabetes mellitus is one of the most common endocrine disorders affecting about 6% of the world’s population. Diabetes mellitus is the leading cause of end stage renal disease (ESRD), a major cau...
Correlation of Serum C-peptide and Serum uric acid Levels with Glycated Hemoglobin in Patients of Type 2 Diabetes Mellitus
Background: Alterations in serum uric acid levels are associated with changes in Blood glucose. While impaired Glucose tolerance is accompanied with increased levels of Uric acid, the levels decrease once overt diabetes...
MDM2 promoter polymorphism (rs2279744) and serum estrogen level are associated with increased risk of epithelial ovarian cancer: A case-control study
Introduction Epithelial ovarian cancer EOC is most common malignancy affecting Indian women One of the transcriptional targets of p53 is human homolog of Murine Double Minute 2 Oncogene MDM2 which is a crucial negative r...
Methylenetetrahydro folatereductase enzyme polymorphism associated with hyperhomocysteinemia in patients with stroke
Cerebrovascular stroke is complex heterogeneous multifactorial disorder associated with number of risk factors, including diabetes mellitus,hypertension, tobacco smoking or chewing; etc. MethylenetetrahydroFolate reducta...
Association between urine albumin creatinine ratio and high sensitivity C-reactive protein in patients with type 2 diabetes mellitus
Introduction Diabetes mellitus is one of the leading causes of morbidity and mortality for its association with complications like nephropathy neuropathy retinopathy and cardiovascular diseases Chronic inflammation plays...