A Study of Serum Levels of Select Heavy Metals and Histology of Brain, Lung, Heart and Ileum of Rats Chronically Exposed to Kerosene
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 6
Abstract
In rural Africa, a number of alternative treatment options are explored because of poverty and unawareness. Kerosene is one such agent used for the treatment of a myriad of diseases. The aim of the study was to investigate the effects of trace amounts of kerosene on lung, heart, brain and intestine in rats. Eighteen rats were used consisting of 6 rats per group. The first and second groups were administered kerosene (0.4 ml of kerosene/kg body weight) through oral and dermal route respectively. Six other rats served as the control. Results showed significant damage to all the tissues examined; with pathologic presentation comprising of pulmonary congestion, severely stunted villi, congestion of coronary vessels, and diffuse spongiosis of the cerebral cortex in kerosene administered group while control group featured no visible lesion. Although As, Al and Cd were not significantly different in kerosene exposed groups compared with control, Si was significantly lower (oral), and significantly increased (dermal) (p<0.05) compared with control. Results of this study suggest that exposure to even small quantities of kerosene may damage a variety of organs/tissues in the body and its exposure to human subjects for whatever reason should be discouraged.
Authors and Affiliations
Ayobola A. Iyanda
Keywords
Related Articles
- EP ID EP344912
- DOI 10.9734/BJPR/2014/2983
- Views 97
- Downloads 0
Solid State Characterization of Two Tropical Starches Modified by Pregelatinization and Acetylation: Potential as Excipients in Pharmaceutical Formulations
Aims: To pre-gelatinize, acetylate and characterize Dioscorea dumetorum (bitter yam) and Dioscorea oppositifolia (Chinese yam) starches using solid-state parameters such as differential scanning calorimetry (DSC), X-ray...
Assessment of Availability of Contraceptive Commodities in Osun State, Nigeria
Background: Family planning (FP) is an important aspect of socio-economic development for which access to contraceptive commodities (CCs) by users is critical. Unfortunately, availability of CCs is usually compromised in...
Polypharmacy in the Elderly: The Need for Concern and Strategies for Its Control
In the last three decades, problems related to aging, multi-morbidity, and polypharmacy have become a prominent issue in global healthcare. In this study, Polypharmacy is defined as a concomitant use of five or more drug...
Methanolic Extract Induced Analgesic and Anti-pyretic Activity of Hemigraphis hirta
Objective: The objective of this research is to investigate the analgesic and antipyretic activity of methanolic extract of Hemigraphis hirta. Methods: Whole dried plant of Hemigraphis hirta was extracted with pure metha...
Identification of n-Hexane Fraction Constituents of Archidium ohioense (Schimp. ex Mull) Extract Using GC-MS Technique
Aims: To screen for the presence of bioactive phytoconstituents in hexane fraction of Archidium ohioense using the GC-MS technique. Study Design: Phytochemical screening via GC-MS technique. Place and Duration of Study...