A study of Serum lipids among children suffering from nephrotic syndrome
Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 9, Issue 1
Abstract
Background:Hyperlipidemia is a common findings in nephrotic syndrome. Thereis increased total Cholesterol, LDL Cholesterol, VLDL cholesterol and lower normal HDL Cholesterol. There is paucity of studies on derangement ofserum lipids with nephrotic syndrome in Indian children. Hyperlipidemia isusually observed during the active phase of disease and disappears with resolution of proteinuria. Objective: A study of Serum lipids among children suffering from nephrotic syndrome. Materials and Methods:A Prospective study was conducted at Basaveshwara Medical College, Chithradurga from January 2018 to June 2018. A total of 60 cases of children with nephrotic syndrome who were admitted for the first time in the pediatric ward our hospital was included in the study.Their clinical status was confirmed by clinical examination and laboratory tests includingurine examination for protein, blood urea, serum cholesterol and serum proteins study included.Results: In our study nearly 76.7% of the study subjects were less than 6 years and 23.3% of them were between the 7 to 12 years.In our study the overall total Cholesterol level, LDL Cholesterol, VLDL Cholesterol, and Triglyceride were found to be much higher than the controls and the association was found to be statistically very significant. Among the cases with steroid sensitive Nephrotic Syndrome the mean cholesterol level was found to be 429.6 mg/dl and 685.9 mg/dl in Steroid Resistant Nephrotic syndrome. Conclusion:Our study concludes that, in nephrotic syndrome, there is generalized hyperlipidemia (except HDL).persistent elevation in the cholesterol levels, which may predispose to development of atherosclerosis and progression to chronic renal failure.
Authors and Affiliations
Srinivasa V, Lakshmi L
Keywords
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