A Study of Stress Induced Biochemical Changes In Pregnancy
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Aim:- To assess the risk of stress induced biochemical changes in pregnancy in view of their significant impact in developing diabetes and coronary heart disease through metabolic syndrome. Materials and Methods:- 15 cases of Primis in first trimester. 15 cases of Primis in third trimester with normal blood pressure. 15 cases of Primis in third trimester with PIH. Fasting blood glucose,Serum total proteins, Serum total triglycerides,Serum total cholesterol, Serum HDLCholesterol and Serum Ceruloplasmin were estimated. Results:- There was increase in levels of fasting glucose, total triglycerides, total cholesterol and ceruloplasmin and decrease in levels of HDL and total proteins as the pregnancy is progressing with further exaggeration in PIH.The change in normal pregnancy is serum hypertriglyceridaemia which may be as high as two to three folds in third trimester over the levels in non pregnant women.A significant decrease in HDL levels were observed in pre-eclamptic pregnant women.Plasma ceruloplasmin (CP) activity increased significantly (p<0.05) as pregnancy progressed.There was 3.60 fold increase in risk of pre-eclampsia among women with total cholesterol > 205mg / dl and 4.15 fold increase in risk of pre-eclampsia among women with triglycerides > 133mg /dl. Conclusion:- The present study concludes that pregnancy is a stressful condition resulting in varied biochemical changes. These changes are exaggerated when pregnant women have associated hypertension which is a risk factor of metabolic syndrome and they are possibly prone to diseases like diabetes mellitus, coronary artery diseases and stroke.
Authors and Affiliations
Dr. Mohana Lakshmi Jonnadula, Dr. Sireesha Maraju
Keywords
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