A Study of the efficacy of caroverine in the treatment of tinnitus
Journal Title: MedPulse -International Medical Journal - Year 2015, Vol 2, Issue 12
Abstract
Introduction: Tinnitus is a common complaint among patients coming for auditory problems. It is a symptom which plagues the sufferer, hinders concentration, prevents sleep and haunts the mental state of the sufferer. Tinnitus prevalence rises with increasing hearing loss . Tinnitus is defined as a perception of sound in proximity to the head with the absence of an external source. It is estimated to occur in 15-20% of the world s population, with 1-3% of the cases severely affecting quality of life. Aims and Objectives: To Study of the Efficacy of Caroverine in the Treatment of Tinnitus. Methodology: The study was conducted on 60 patients of age 20-80 years and of either sex who presented with chronic tinnitus between July 2012 to July 2014, to the ENT OPD of MGM Hospital and Medical College, Aurangabad. All the patients of tinnitus were randomly divided into two groups, 1) group Acaroverine and 2) group B placebo. For treatment, all patients received a single infusion of 100ml physiological saline solution. The caroverine group A (n=30), the saline solution contained 160mg caroverine (4 ampoules of 40mg caroverine each). In the placebo group B (n=30), only the physiological saline solution was given Descriptive and inferential statistical analysis has been carried out in the present study. Results on continuous measurements are presented on Mean ± SD (Min-Max) and results on categorical measurements are presented in Number (%).Student t test (two tailed, independent) has been used to find the significance of study parameters on continuous scale between two groups Inter group analysis) on metric parameters . Student t test (two tailed, dependent) has been used to find the significance of study parameters on continuous scale within each group. Chi-square/ Fisher Exact test has been used to find the significance of study parameters on categorical scale between two or more groups. McNemar test has been used to find the significance of change in each for pre and Post treatment. Result: THI score post treatment with caroverine showed statistically significant reduction in the immediate and 1st week post infusion period with p value = 0.002.The study showed 63.3% responded to caroverine therapy immediately after infusion. Our study looked at the effectiveness of caroverine in a selected placebo controlled group of patients. This study revealed that THI score post treatment with single infusion of caroverine had significant improvement in tinnitus severity immediately and at the first week, but no improvement in the fourth week and at 6 month follows up. Conclusion: Use of caroverine helps in reducing tinnitus in the immediate and first week post treatment.Caroverine is effective as a modality of treatment in suppressing tinnitus on short term basis.
Authors and Affiliations
Rajendra B Bohra, Suma Moni Mathew, Tanvi Kaustubh Patil
Keywords
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