A Study of use of High Performance Liquid Chromatography (HPLC) for diagnosis of Thalassemia
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 7
Abstract
Hemoglobinopathies represents a group of disorders with altered gene mutations running in families that results in variety of disorders. This makes a large number of pools of patients in general population. Many a time’s traits of various hemoglobinopathies go undetected and thus increases morbidity. If we could detect these conditions earlier then we can limit morbidity and spread in general population through family extension giving a better life for patients. Thus, the present study carried out to use High Performance Liquid Chromatography in diagnosis of thalassemia and screening of family members of affected individuals with aim to study clinical features, hematological parameters and HPLC findings in patients of Thalassemia. This study included total 127 cases of thalassemia and divided into five groups as thalassemia major- group A, thalassemia minor-group B, Sß+ - group C, Sß0 - group D and group rare included thalassemia intermedia, delta beta thalassemia, double heterozygous for S and E, etc. maximum number of cases were seen in the age group of 0-10 years in thalassemia major, and 21-30 years in thalassemia trait. Buddhists was common religion having affected individuals. In clinical presentation pallor was common symptom, splenomegaly was seen in Sß0, hepatomegaly in thalassemia major. All hematological parameters were reduced in hemoglobinopathies as compared to control group. Thus to conclude HPLC is useful method for diagnosis of thalassemia
Authors and Affiliations
Dr. Pradnya S Bhadarge
Keywords
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