Vulvar Cancer – A Rare Diagnosis in Identical Twins
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Vulvar cancer is a rare neoplasm, accounting for 4% of gynecological cancers, 90% of which are squamous cell carcinomas. This tumour is more frequent in postmenopausal women, with a peak incidence in the 6th to 7th decades of life. Clinically, patients may present with vulvar ulcer, bleeding, pain, edema and leukoplakia but severe pruritus is the most common symptom. Diagnosis is based on the histological examination and the treatment is surgical. Vulvar cancer might be curable in early stages, but in locally advanced disease is associated with a poor 5 year survival rate. The authors describe two case reports of identical twins with malignant vulvar neoplasia. In literature, only one case of this malignancy is described in two twin sisters. This fact raises the hypothesis of a genetic component in the etiology of the disease.
Authors and Affiliations
Mariana Carlos Alves
Keywords
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