Comparative Study of Fine Needle Aspiration Cytology and Cell Block Technique in Lymphadenopathy
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 7
Abstract
Lymphadenopathy is recognized as a common sign of infectious, autoimmune, or malignant disease. Most of the times, infection is the main cause of lymphadenopathy but proper treatment can be persuaded by exact diagnosis. Fine needle Aspiration Cytology plays important role in diagnosing lymphadenopathy having high sensitivity and specificity. But there are conditions in which fine needle aspiration cytology fails to give exact diagnosis. In these cases the diagnostic utility of fine needle aspiration cytology can be reckoned with use of cell block technique. Thus, the present study was conducted with aim to compare fine needle aspiration cytology and cell block technique in lymphadenopathy and to study advantages of cell block technique. Total 91 patients were studied and results revealed maximum number cases in the age group of 20-40 years with nearly equal M:F ratio and cervical lymph node being commonest aspirated one. Malignant cases outnumbered benign conditions on both fine needle aspiration cytology and cell block technique. 4 cases were inconclusive on fine needle aspiration cytology while only one case was inconclusive on cell block technique. Tuberculous lymphadenitis and metastasis of squamous cell carcinoma were commonly diagnosed conditions both on fine needle aspiration cytology and cell block. Cell block picked one more case each of reactive lymphadenitis, tubercular lymphadenitis and metastasis of squamous cell carcinoma. Two cases of squamous cell carcinoma were misdiagnosed on fine needle aspiration cytology. One case was reported as metastasis of adenosquamous carcinoma and other one reported as squamous cell carcinoma with tuberculous lymphadenitis on cell block. These results concluded that cell block has higher sensitivity and specificity than fine needle aspiration cytology. Thus fine needle aspiration cytology in conjunction with cell block technique can increase the diagnostic accuracy of the disease with the advantage of providing cell block section for immunocytochemistry and immunohistochemistry.
Authors and Affiliations
Dr. Pradnya S Bhadarge
Keywords
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