A study of various haematological parameters in patients with non-haematological malignancies with reference to age and sex

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A study of various haematological parameters in patients with non-haematological malignancies with reference to age and sex

Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 4

Abstract

Introduction: A survey of 38 studies, most of which evaluated anaemia prevalence in cancer patients before treatment found that the prevalence ranged from 5% (prostate cancer) to as high as 90% (multiple myeloma).The prevalence of anaemia appears to be especially high in patients with uterine-cervical cancers, advanced multiple myeloma and those suffering from cancer- related renal impairment. Aims and Objectives: To Study various haematological parameters in patients with non-haematological malignancies with reference to Age and Sex. Methodology: This study was carried out in the department of Clinical Pathology on the patients admitted to an urban referral hospital. A total number of 40 inpatients with various nonhaematological malignancies were screened for anaemia. Based on Hb cut-off of 12 g/dL, 33 of them were recruited for the study. Complete haemogram was done using Sysmex KX-21, fully automated haematology analyzer (manufacturers: Sysmex Corporation, Japan). Statistical analysis was done by ANOVA and Unpaired –t test. Result: In our study we have found that Mean Haemoglobin levels varied significantly based on age. When ANOVA test was conducted (F=3.246; P<0.05) the mean Hb level was highest in the age group of 41 – 50 years (10.78 g/dL) and lowest in the age group of 61– 69 years (9.04 g/dL) .Mean RBC count varied significantly based on age .When ANOVA test was conducted (F=3.089; P<0.05) the mean RBC count was highest in the age group of 19-40 years (4.42 million/mm3) and lowest in the age group of 61–69 years (3.59 million/mm3).Mean haematocrit varied significantly based on age .When ANOVA test was conducted (F=5.566; P<0.01) the mean haematocrit was highest in the age group of 19- 40 years (36.10%) and lowest in the age group of 61–69 years (29.59%).Mean Haemoglobin levels did not vary significantly between men and women. When t-test was applied (t=1.232; P>0.05)) the average Hb in men was 9.50 g/dL whereas for women it was 10.28 g/dL. Mean RBC count did not vary significantly between men and women. When t-test was applied (t=0.075; P>0.05)) the average RBC count in men was 3.89 million/mm3 whereas for women it was 3.91 million/mm3 Mean Haematocrit did not vary significantly between men and women. When t-test was applied (t=1.463; P>0.05)) the average HCT in men was 30.94% whereas for women it was 33.34% Conclusion: From this it is clear that the with increasing age the anemia is increasing significantly in older age while there is no role of sex in anaemia with non haematological malignancies.

Authors and Affiliations

R Palaniswamy, K M Selvanayaki

Keywords

Non-Haematological Malignancies Haematological Parameters.

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EP ID EP205297
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