A study on comparison of monotherapy versus combination therapy for hypertensive patients at tertiary care hospital
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 1
Abstract
Objective:To compare the therapeutic benefit of monotherapy and multiple therapy by assessing clinical outcome (BP measurement), To address and document the various adverse effects observed during monotherapy and multiple therapies for hypertensive patients, To compare the cost of both therapies during the treatment. Material and Methods:Two groups were included during the period of study, monotherapy and second group who received multiple therapy( dual therapy, triple therapy, quadruple therapy) ; Comparative study was done by measuring the outcome clinically by observing change in the BP. safety of the treatment regimen was assessed by observing the ADRs and cost comparison was carried out between the groups. ANOVA test was applied to check the statistical significance of the above mentioned parameters. Results: Out of total 200 patients, most of the patients (127) were females and the remaining (73) were males. Among 200 patients enrolled, 152 patients had hypertension along with other co morbidities and diabetes was the most common co morbid condition which was present in 126 patients. Most of patients were treated with monotherapy (96) which was followed by dual therapy (76). In monotherapy T.Furosemide reduced SBP by 50 mmHg and T.Nifedipine and T.Metoprolol Reduced DBP by 20 mmHg, whereas in dual therapy Inj. furosemide, T.Metoprolol decreased mean SBP by 60 mmHg and DBP by 40 mmHg respectively. Results showed that, triple drug therapy was most effective in reducing mean systolic (41.8-24%) and mean diastolic blood pressure (16.8-16.6%) and reduction of SBP by triple therapy was higher compared to other therapies. Conclusion: Combination therapy reduces both mean systolic and diastolic blood pressure compared to monotherapy. Triple drug therapy is more effective compared to dual and quadruple therapy. Pedal edema due to amlodipine is the most common ADR in both mono and multiple therapies. Combination therapy is more expensive than monotherapy, however triple therapy was most expensive compared to others.
Authors and Affiliations
Sara Azad
Keywords
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