Evaluation of hypoglycaemic activity of shilajit in alloxan induced diabetic rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2017, Vol 6, Issue 3
Abstract
Background Diabetes mellitus is a potentially morbid condition with high prevalence worldwide. This disease constitutes a major health concern affecting about 2.8% of the global population. Currently available synthetic antidiabetic agents produce serious side effects. This leads to a demand for herbal products with antidiabetic activity and fewer side effects. Hence shilajit a herbo- mineral substance with a wide spectrum of biological activity is being evaluated for its anti diabetic activity. Aim of the study To evaluate the hypoglycemic activity of shilajit in alloxan induced diabetic rat model and to compare hypoglycaemic activity of shilajit with standard drug, glibenclamide. Materials and Methods Alloxan induced (150mg/kg.i.p) diabetic rats were divided into six groups of six animals each weighing 150-200 gms. Group I - Diabetic control: Normal saline. Group II - Standard: Normal saline + Glibenclamide (5mg/kg). Group III – Normal saline + Shilajit dose D1 50mg/kg, Group IV- Normal saline + Shilajit dose D2 100mg/kg, Group V- Normal saline + Shilajit dose D3 150mg/kg, Group VI- Normal saline + Shilajit dose D2 100mg/kg+ Glibenclamide (5mg/kg). All drugs are given once daily orally for 21 days and fasting blood glucose was estimated from blood taken from rat tail vein using glucometer on 0, 7th, 14th, 21st days. Results Shilajit by itself has significant hypoglycemic effect. Its hypoglycemic effect is comparable to glibenclamide when used in doses 50mg/kg, 100mg/kg, but when used in dose of 150mg/dl it showed lesser effect. Shilajit when combined with glibenclamide showed potentiated hypoglycemic effect. Conclusions The result in this study suggests that shilajit can be used as monotherapy in doses 50mg/kg, 100mg/kg and complementary medicine with glibenclamide for diabetes mellitus.
Authors and Affiliations
Ravi H Kudthni
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