A Study on Contrast-Induced Nephropathy Following Emergent And Elective Percutaneous Coronary And Peripheral Intervention: Diagnosis Through Biomarkers As Serum Creatinine And Cystatin C
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 10
Abstract
Objective: It was aiming to know the diagnostic efficacy of biomarkers as serum creatinine (SCr) and serum cystatine C (SCysC) to evaluate prognosis of CIN in the hospital-admitted patients among eastern Indians. Methods: 100 patients were selected for primary coronary angioplasty between February2015 – January2016. Out of 100 patients, 95 patients were evaluated for development of CIN and categorized into CIN and non-CIN groups, which was further divided into male, female and combination of them. SCr value was checked on day-1 (baseline), after 24hr (day-2) and 48hr (day-3). SCysC value was also estimated on day-1 (baseline) and after 24hr (day-2). Statistical analyses were done in all groups at P<0.05 level. Results: The prospective study revealed that day-1 SCr values were significantly (P<0.01) higher in combined and male patients but in females no significant difference was observed for the CIN groups compared with nonCIN groups. The significantly increased values were also observed in both combined (P<0.001) and males (P<0.01) for day-2 and 3, when compared between CIN and non-CIN groups. But for female patients only significant difference (P<0.05) was found on day-3 SCr. Another marker, SCysC was also increased without statistical significant values in CIN groups after 24h duration, when compared to day-1. But in non-CIN groups, SCysC was found in decreasing trend with statistically significant (P<0.001, P<0.001 and P<0.05) for all groups in comparison with day-1. For diagnostic accuracy in relation to SCr and SCysC, it was observed that 78.95%, 81.71% and 61.54% for combined, males and females respectively. Conclusion: The novel biomarker SCysC can be suitable diagnostic tool to predict the occurrence at early stage (24hr duration) of CIN. The present results revealed that SCysC was decreased indicating renal function improvement after intravenous fluid therapy.
Authors and Affiliations
Mousumi Kundu, Swapan Kumar Halder, Biswarup Mukherjee, Pinaki Mukherjee, Utpal Kumar Biswas, Priyanka Datta
Keywords
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- EP ID EP244346
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