A Study on Culture and Sensitivity Pattern in Urinary Tract Infections of Febrile Children
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: Urinary tract infection (UTI) is one of the most common source of infection in febrile children under 5 years of age. Early diagnosis and appropriate treatment can significantly decrease late serious complications. Knowledge of the sensitivity and resistance pattern of uropathogens in specific geographical locations is an important factor for choosing suitable antibacterial treatment. Material and methods: This observational study was conducted in order to evaluate the culture and sensitivity pattern of uropathogens at a tertiary care teaching hospital over a period of 18 months after institutional ethical committee approval. Cultures were performed on urinary samples collected by sterile urine bags in infants and mid-stream urine in children with blood and Mac Conkey agar plates at 35-37 C under aerobic coditions. Antibiotic sensitivity was measured by using the clinical laboratory standard institute (CLSI) guidelines. All the data was recorded in a predesigned proforma after taking consent from the parents and analysed using the appropriate statistical methods. Results: Out of 422 febrile children, 85(20.1%) cases showed more than 5 pus cells per high power field on microscopy, 38 cases were found to be culture positive giving rise to an incidence of 9% in our study. UTI was more common in males in first year of age and in females beyond 1 year. The most common organism isolated was E.coli in 25 (65.7%) cases, followed by Klebsiella in 6(15.8%) and other organisms in few cases. These organisms were mostly sensitive to gentamycin (94.7%), ciprofloxacin (92%), ceftriaxone (89.4%) and resistant to the common urinary tract antibiotics like ampicillin (13.1%), amoxy-clavulinic acid (18.4%) and co-trimoxazole (26.3%). Conclusion: All children with febrile UTI should be started with early and appropriate antibiotics to prevent long term complications especially end stage renal disease in the future. This requires regular monitoring of antimicrobial culture and sensitivity patterns to know the appropriate common local antibiotics for febrile UTI, so that empiric therapy with antibiotics could be started early to prevent long term complications in children.
Authors and Affiliations
Ravi Kiran CH, Thirupathi Reddy A, Ramesh Kumar B
Keywords
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