To Evaluate the Analgesic Efficacy of Port Site Infiltration of Dexmedetomidine for Postoperative Pain Relief after Laproscopic Procedure in Comparison with Bupivacaine
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Laproscopic procedures have advantages such as less haemorrage, better cosmetic results, lesser post operative time causing lesser hospital stay and less expenditure. The aim of this study was to compare the analgesic efficacy of port-site infiltration of bupivacaine with Dexmedetomidine and placebo in reducing postoperative pain after laparoscopic procedures. Material and Methods: The study was carried out in the department of Anaesthesia AVBRH, a unit of Jawaharlal Nehru Medical College Sawangi Wardha, from December 2016 – December 2017. At the end of surgery, the study Group I (GI) received 50 mL saline; Group II (GII), received 50 mL bupivacaine 0.25% (125 mg) and Group III (GIII),0.25% (125 mg)+1μg/kg Dex (Dexmedetomidine) equally at all the ports sites. Assessment of postoperative pain was based on a 0 to 10 visual analogue scale (VAS, 0: no pain, 10: the worst imaginable pain) at 0, 4, 8, 12 hours postoperatively. Results: Demographic data, in type of surgery, and duration showed no significant difference between the groups (P>0.05). There was no significant differences regarding hemodynamic variables (NIBP, pulse rate) measured during the intraoperative and postoperative period and in sedation scores among all of the groups (P>0.05). There was a significant reduction in pain as measured by VAS in GIII at baseline, 2 hours, 4hours, and 24 hours postoperatively in comparison to the other two groups (P<0.05). The time of the first rescue analgesic requirement was significantly prolonged in GIII (9.5067.5) in comparison to other two groups (P50.002), with no significant differences observed between GI (0.6060.6) and GII (0.8060.7). Conclusion: Portsite administration of 1 mcg/ kg Dexmedetomidine combined with bupivacaine provides better quality and duration of analgesia and has an analgesicsparing effect compared with bupivacaine alone without significant adverse effects in patients undergoing Laparoscopy cholecystectomy surgery.
Authors and Affiliations
Nandkishor Agrawal, Shreshtha Singh
Keywords
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