Comparision of Palonosetron with Ondansetron for Prevention of Nausea and Vomiting during Postoperative Period in Patients Undergoing ENT Surgeries
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Postoperative nausea and vomiting (PONV) is a common complication in patients after ENT surgeries conducted under general anaesthesia. The objective of the present study is to compare the intravenous Palonosetron with intravenous Ondansetron for prevention of nausea and vomiting during postoperative period in patients undergoing ENT Surgeries under General Anaesthesia. Material and methods: This was a randomized double blind clinical study conducted on 60 ASA Grade I&II patients scheduled for ENT Surgeries under General Anaesthesia and were randomly divided into two groups, Group I and Group II, each consisting of 30 patients. Group I received 4 mg of Ondansetron I.V and Group II received 1.5 mcg/kg of Palonosetron I.V, 30 minutes before the induction of anaesthesia. The incidences of PONV were recorded with in the first 72 hours after surgery at intervals of: 0-12 hours, 12-24 hours and 24-72 hours. Episodes of PONV were identified by spontaneous complaints by the patients, by direct questioning and by Nausea Scale (Visual Analogue Scale) 0 -10. Results: There were no differences in the demographic data between the two study groups. The incidence of PONV was significantly less in the palonosetron group (5.55%) as compared to the ondansetron group (43.33%), with a lesser need for rescue antiemetic in the palonosetron group (10% vs. 53%). Both the study groups did not have significant adverse effects reflecting that both the drugs were well-tolerated. Conclusion: In conclusion, we have found that Palonosetron at a dose of 1.5mcg/Kg IV is safe and well-tolerated and proved more effective than Ondansetron 4 mg IV in the prevention of PONV.
Authors and Affiliations
J. Sambasiva Rao, C. Geetha, R. Pandu Naik
Keywords
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