Zinc Deficiency in Patients with Recurrent Aphthous Stomatitis: A Pilot Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 12
Abstract
Introduction: Recurrent aphthous stomatitis is a common disease of the oral mucosa, affecting 20 per cent of the general population. However, the aetiology of this disease is unknown. This study is done to compare zinc levels in recurrent aphthous stomatitis patients with those of a wellmatched, healthy, control population. Meterial and Methods: Twenty-five subjects with a history of minor recurrent aphthous stomatitis and 25 healthy subjects (control group) took part in the study. Patients aged between 20 and 40 years with recurrent oral aphthous ulcers less than or equal to 1 cm in diameter were included. Exclusion criteria were pregnancy and lactation, systemic disease (ulcerative colitis, Crohn’s disease, Behçet’s disease), any current medication (topical or systemic), dental surgery during the previous month and deficiencies in iron, folic acid or vitamin B1, B2, B6 or B12. Serum zinc levels were compared between patient and control groups. Results: Zinc deficiency was detected in 29 per cent of recurrent aphthous stomatitis patients and in 5 per cent of controls. The mean serum zinc level in the patient group was significantly lower than in the control group. Conclusion: These results suggest an association between zinc deficiency and recurrent aphthous stomatitis.
Authors and Affiliations
Rizwan Hamid, Altaf Chalkoo, Saima Ashawari, Gazanfer Shah, Ubaid Ullah Gul Salmani
Keywords
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