The Effects of Oral Sodium Bicarbonate Treatment on Hematological Parameters in Patients with Chronic Kidney Disease During the Predialysis Period
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 5
Abstract
Introduction: Chronic renal disease (CKD) is a serious public health problem with high treatment costs, that leads to an increase in mortality and morbidity, and impairs the quality of life. This study was performed to evaluate the effect of improvement of metabolic acidosis seen in chronic renal disease by oral sodium bicarbonate treatment on hematological parameters. Material and Methods: This study was consisted of 111 patients with chronic renal disease and datas scanned, retrospectively. Then, 62 ones in the predialysis period and received oral sodium bicarbonate treatment were followed up. Patients divided into two groups, group A (n:37) patients who had persisted metabolic acidosis though oral sodium bicarbonate treatment (HCO3<22 mEq/L) and group B (n:25) patients who were treated sufficiently (HCO3>22 mEq/L), at the end of study. Results: Hematological parameters as hemoglobin, hematocrit, leukocyte and platelet counts of all patients were analyzed at the beginning and end of the study. Mean hemoglobin, leukocyte and platelet counts were similar between groups at the begining (p value 0.611, 0.314 and 0.840, respectively). In addition, no significant difference was found in mean hemoglobin, leukocyte and platelet counts after 3 months (p value 0.713, 0.277 and 0.937, respectively) Conclusion: Correction of metabolic acidosis secondary to chronic renal disease by sodium bicarbonate treatment had no effect on anemia and other hematologic parameters in predialysis period.
Authors and Affiliations
Tayyibe Saler, Mehmet Bankir, Serkan Duman, Sibel Ada, Betül Çavuşoğlu Türker, Süleyman Ahbab
Keywords
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