Study of Non-alcoholic Fatty Liver Disease and its Association with Coronary Artery Disease
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 7
Abstract
Introduction: Non Alcoholic fatty liver disease (NAFLD) is a variety of fatty liver which occurs due to hepatic steatosis, caused by other than excessive alcohol use. Data suggests that NAFLD is also an independent risk factor of cardiovascular disease, which remains the commonest cause of mortality in such patients. This study was conducted to estimate the prevalence of NAFLD diagnosed by ultrasound examination of the liver in type 2 diabetes mellitus (DM). Secondary objective was to demonstrate association between NAFLD and coronary artery disease (CAD) in type 2 DM. Material and methods: This was an observational study conducted at Department of General Medicine of a tertiary care centre for 2 years. 500 adult patients (age >18 years) of type 2 DM were evaluated for NAFLD, CAD and other cardiovascular risk factors. Microsoft Excel software and SPSS version 20 for Windows were used for data storage and analysis. Results: The incidence of NAFLD was 44% in all diabetics, among them males were affected more (50%) than females (40%). Mean BMI was 27.8 and 27.2 among males and females respectively. NAFLD subjects had higher incidence of smoking, hypertension, obesity, dyslipidemia, uncontrolled sugar and CAD than Non-NAFLD group subjects. These differences were statistically significant. Conclusion: We should have high index of suspicion of NAFLD in diabetics. Possibility of NAFLD increases if patients have metabolic syndrome. If found, we should manage risk factors for CAD aggressively as patients have high chances of developing CAD in diabetics with NAFLD
Authors and Affiliations
Nikhil Bakhtar, Sarvagya Mishra, Abhishek Singhai, Rajesh kumar Jha
Keywords
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