Association of Pulse Pressure and Diurnal Blood Pressure Variation with Micro- and Macrovascular Complications in Type 2 Diabetes in Rohilkhand Region
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: In non-diabetic persons pulse pressure (PP) is an independent predictor of cardiovascular disease microalbuminuria. Reduced circadian blood pressure (BP) variation is a potential risk factor for the development of diabetic complication. We investigated association between retinopathy, nephropathy, macrovascular disease, PP and diurnal BP variation in a group of type 2 diabetes patients. Material and methods: In 100 type 2 diabetic patients we performed 24 hr ambulatory BP (AMBP) and fundoscopy, urinary albumin excretion was evaluated by urinary albumin/ creatinine ratio. Presence and absence of macrovascular disease was assessed. Result: 61 patients had no detectable retinal changes (grade 1), 15 had grade 2 retinopathy, 24 had more advanced retinopathy (grade 3-6). Compared to patients without retinopathy (grade 1), patients with grade 2 and 3-6 had higher PP and blurted diurnal BP variation. Comparing nephropathy group (58 normal, 24 microalbuminuric, 18 macroalbuminuric patients). Results are similar likewise compared to patients without macrovascular disease (n=69), patients with this complication (n=31) had higher AMBP value. Conclusion: Increased PP and blurted diurnal BP variation are hemodynamic abnormalities associated with micro and macrovascular complication in type 2 diabetes mellitus.
Authors and Affiliations
Abhishek Kumar Verma, Rahul Kumar Sinha, Nikhil Saxena
Keywords
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