A Study on Effects of TSH Suppression Therapy in Hypothyroidism
Journal Title: International Physiology - Year 2017, Vol 5, Issue 2
Abstract
Background: Thyroid disease is one of the most common endocrine problems managed by general physicians in the endocrinology practice. Hypothyroidism as a clinical syndrome was recognized even later than hyperthyroidism and at first its cause was equally obscure. Common causes of Hypothyroidism are Iodine deficiency, Auto immunity like Atrophic Thyroiditis, Hashimoto’s thyroiditis, Drug Induced Hypothyroidism. Methods: The study comprised of 40 subjects, classified into 2 groups each, with 20 subjects. Group I – 20 (Healthy individuals) controls aged between 20–45 years with euthyroid status. Group II20 Hypothyroid subjects with suppressed levels of TSH aged between 20 to 45 years. The parameter like T3, T4, TSH, Ca+2, Po4 3, ALP, PTH and 25OH VitDmeasured. Results: The mean value of TSH was 2.42±1.08 in controls and 0.15±0.00 was in hypothyroid treated, the mean value of T4 was 98.45±21.92 in controls and 139.65±37.90 was in hypothyroid treated, the mean value of T3 was 1.25±0.33 in controls and1.36±0.48 was in hypothyroid treated.The mean value of mean bone mineral area in lumbar spine, femur neck and radius & ulna were 47.53±3.80, 4.47±0.35 and 4.50±0.45 respectively. The mean value of bone mineral area in lumbar spine is less compared to controls. Themean values bone mineral density of lumbar spine, femur neck, and radius & ulna were 39.47+5.07, 3.23+0.54 and 2.89+0.43 respectively. Conclusion: The patients on long term treatment of drugs likelevothyroxine, in spite of treating hypothyroidism there is aloss of bone mineral density although not with a higherfracture rate due to suppression of TSH levels.
Authors and Affiliations
Ashwini S. a
Keywords
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- EP ID EP461922
- DOI 10.21088/ip.2347.1506.5217.11
- Views 99
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