A STUDY ON EVALUATION OF ISCHAEMIA MODIFIED ALBUMIN AND ITS RELATIONSHIP IN HYPERTHYROIDISM
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 89
Abstract
BACKGROUND Hyperthyroidism is characterised by increased levels of thyroid hormones leading to hypermetabolic state. More common in females than males with sex ratio of up to 5:1. Thyroid hormone functions as a stimulus to metabolism and is critical for normal functioning of the cell. Under oxidative stress, Ischaemia Modified Albumin (IMA) is considered as one of the marker of ischaemiareperfusion injury. Albumin has the tendency to attach to metals like copper and cobalt at N- terminus. Ischaemic conditions make albumin to lose its capacity to bind to metal ions due to change in its structural confirmation at the binding site. Aim- This study was done to evaluate IMA and its relationship in hyperthyroidism. MATERIALS AND METHODS A descriptive, comparative study was done with 30 newly diagnosed hyperthyroid patients with elevated T3, T4 values and decreased TSH values were considered as cases, and 30 age and sex matched individuals with normal thyroid function tests were considered as controls. Thyroid profile was done by Enzyme linked immunofluorescent assay and IMA was estimated by colorimetric methodology. Statistical Analysis- Independent sample t test was used. Statistical analysis was done by using SPSS version 13.0 (Statistical Package for the Social Sciences). Values are expressed as Mean ± SD, p value <0.05 was considered significant. RESULTS Ischaemia Modified Albumin levels were found to be significantly increased in hyperthyroid patients (0.73 ± 0.10 OD units) when compared to healthy controls (0.28 ± 0.01 OD units) (p=0.00). CONCLUSION Our study shows that there is significant elevation in IMA levels which may be due to the consequence of oxidative stress and ischaemia prevailing in hyperthyroid state.
Authors and Affiliations
Jyoti B, Rangaswamy R
Keywords
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- EP ID EP277967
- DOI 10.14260/jemds/2017/1353
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