A study on genotypic frequency of 12-lipoxygenase polymorphisms and 12-HETE levels in type II diabetes
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 3
Abstract
Background: Diabetes mellitus describes a group of metabolic diseases characterized by a progressive insulin secretory defect due to insulin resistance resulting in high glucose levels in the blood. Approximately 90% of all the cases of diabetes worldwide are type II Diabetes Mellitus where enough insulin is not produced for proper function. Growing body of evidence has suggested that beta cell inflammation and dysfunction play a key role in the pathogenesis of type II diabetes. Obesity and lack of exercise are some of the contributory factors for type II diabetes mellitus. A class of enzymes called lipoxygenases and derived oxidized lipids induces inflammation of beta cells and has been implicated in diabetes development. Studies show that the genetic deletion of 12-lipoxygenase (12-LOX) decreases the activity of 12- LOX and further decrease beta cell inflammation and dysfunction. Hence our main objective was to study the polymorphisms of 12-LOX gene in type II diabetes. Materials and Methods: Study participants included were in the age group of 30-70 years. 30 diagnosed patients of diabetes with the minimum history of 3 years were selected as cases. Equal number of age and sex matched healthy individuals were included in the control group. A detailed clinical history, family history and demographic details were collected from the subjects. Body Mass Index (BMI), HbA1c levels, Plasma 12-Hydroxyeicosatetraeinoic acid (12-HETE) levels and 12-LOX gene polymorphisms were assessed. Results and Conclusion: We observed significant difference in the routine parameters such as Fasting blood sugar (FBS), HbA1c and BMI whereas the 12-HETE levels did not show any significant difference between diabetic and non-diabetic subjects. Polymorphism study revealed varied genotype distribution of G>A and C>T gene clusters but again did not show any significance.
Authors and Affiliations
Suma M Nataraj, Devananda Devegowda, Anisha Mathai, Ankita Mysore Amarbabu, Arpitha Bankenhalli Jayaram, Pushkal Sinduvadi Ramesh, Swetha Kempegowda
Keywords
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