Serum fasting lipid profile and lipoprotein(a) in northern keralite patients with myocardial infarction
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 3
Abstract
Coronary artery disease isrising as a major health problem in Kerala. The presentstudy was aimed to verify whether there is increase in the concentration of Lipoprotein (a) [Lp(a)] and fasting serum lipid profile in Northern Keralite Myocardial infarction(MI) patients. Fasting blood samples were taken from 606 patients and their total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol, triglycerides and serum Lp(a) were determined. The control group consisted of 615 age matched healthy individuals. The mean serum levels of Lp(a) levels were found significantly higher in patients with MI (p<0.0001) as compared to the controls. The values were 24.15 ± 0.75 and 8.6 ± 0.34 mg/dl in the test and control groups respectively. The mean values of serum cholesterol were increased significantly (p<0.0001) in test group (205 ± 1.86 mg %) when compared to the control (174 ± 0.74 mg %).Similarly, the mean values of serum LDL cholesterol were increased significantly (p<0.0001) in test group (137 ± 1.68 mg %) when compared to the control (108 ± .69 mg %).Whereas, the mean values of serum HDL cholesterol were decreased significantly (p<0.030)in test group (42 ± 0.38 mg %) when compared to the control group (45 ± 0.39 mg %). Besides, the mean values of serum triglycerides (TG) were increased significantly (p<0.0001) in test group (132 ± 3.31 mg %) when compared to the healthy control subjects (109 ±1.20 mg %). The results of this study suggest that high level of Lp(a), LDL, TG and low levels of HDL have a distinctive association with MI, independent of other common coronary risk factors. Henceforth, Lp(a) level in serum appears to be a promising marker for diagnosis of coronary artery diseases.
Authors and Affiliations
Sachilkumar Mattilayimmal, Pradeep Kumar KM
Keywords
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- EP ID EP521740
- DOI 10.26611/1002935
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