Relationship between glycosylated haemoglobin and risk of microalbuminuria in patients with type 2 diabetes mellitus
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 1
Abstract
Diabetes mellitus (DM) is one of the most common chronic diseases in most countries. Diabetic nephropathy (DN) is one of the most common complications, and an important cause of renal failure. Microalbuminuria is the earliest clinically detectable stage of diabetic kidney disease at which appropriate interventions can retard, or even reverse, the progress of nephropathy. Glycosylated haemoglobin (GHb) is a useful index of mean glycaemia during the preceding 120 days. It is also a predictor of complications as measures reducing HbA1c correspondingly reduce the risk of complications. The present study was done to evaluate the relationship between duration of diabetes, degree of hyperglycemia and the incidence of microalbuminuria in patients with diabetes mellitus. Methods: It was Prospective Study, subjects were chosen from the Out Patient Department and Indoor Patient Department of Medicine, M.G.M. Medical College and L.S.K. Hospital, Kishanganj, Bihar, from the population in the city of Kishanganj and peripheral villages of Kishanganj District. The duration of study was from December 2015 to August 2017. The study group consists hundred cases of 20-60 years age group from rural and urban area after following the exclusion and inclusion criteria. We divided hundred patients in four age groups i.e. 20-30 years, 31-40 years, 41-50 years and 51-60 years of age group. A short history and clinical examination of the patients were obtained regarding the blood pressure, history of smoking, alcohol intake and after taking the verbal consent of the patient after that blood and Urine samples were collected. Blood and Urine samples were tested in the Department of Biochemistry, M.G.M. Medical College and L.S.K. Hospital, Kishanganj, Bihar. Results: In the present study we divided total 100 patients in four age groups out of them 58 were male and 42 we female. Maximum number of patients belongs to 51-60 years of age group. Among them 34% (17) were male and 26% (13) were female. Present study showed a positive correlation of microalbuminuria with duration of diabetes and level of glycaemic control (measured by HbA1c levels), which is in accordance with many previous reports. Also, presence of concomitant hypertension and smoking were important risk factors in early development of nephropathy. Therefore, regular screening for microalbuminuria in addition to continuous HbA1c estimation are important tools in the management of DM. Conclusion: It was concluded that the prevalence of microalbuminuria in diabetic patients in this study was found to be as high, which needs of therapeutic and preventive measures. Being a developing country, there is a need of microalbuminuria and HbA1C testing in both newly diagnosed as well as already diagnosed type 2 diabetic patients as an early marker of renal risk factor.
Authors and Affiliations
Amrita . , Shiv Shankar Bharti
Keywords
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- EP ID EP521663
- DOI 10.26611/1002915
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