Serum lipid profile and Psoriasis – A case control study
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 1
Abstract
Background: Psoriasis is a chronic inflammatory skin disease characterized by excessive cellular replication. It is associated with an atherogenic lipid profile. The prevalence of cardiovascular disorders in these patients is remarkably higher compared to normal individuals, which seems to be associated with the hyperlipidemia. This study was designed to study the serum lipid profilelevels in psoriatic patients to see its association with the severity of disease. Objectives: To evaluate serum lipid profile in serum of patients with psoriasis. Materials and Methods: It is a case control study. The study was conducted on 60 clinically diagnosed patients of psoriasis attending the outpatient department (OPD) of dermatology. Sixty (60) age and sex matched healthy subjects were taken as controls. Venous blood sample of 5 ml was collected, serum was separated and serum lipid profile was measured – total cholesterol (TC), triglycerides (TGL), high density lipoprotein (HDL). Results: Serum TC, TGL, low density lipoprotein(LDL) and Very low density lipoprotein (VLDL) levels were significantly increased in cases of psoriasis as compared to controls (p<0.001). Serum HDL levels were significantly reduced in cases of psoriasis as compared to healthy controls. Conclusion: Our study showed a significantly elevated levels of serum lipids in cases, which may aggravate the risk of atherosclerosis and other cardiovascular disorders. So screening of diagnosed cases for lipid profile is recommended to reduce the further compications.
Authors and Affiliations
Arati Ganiger, K Mallikarjuna Swamy
Keywords
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