A study of serum Cystatin C levels in type 2 diabetes mellitus patients with normoalbuminuria, microalbuminuria and macroalbuminuria
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 7, Issue 2
Abstract
Background: Diabetic nephropathy, a major microvascular complication of diabetes mellitus, is a leading cause of endstage renal disease. Early detection of renal dysfunction is the only way to avoid the morbidity and mortality in type 2 diabetes mellitus(T2DM). Many studies have demonstrated that serum cystatin C is an accurate and sensitive marker for detecting early renal impairment in T2DM. Hence this study was done to assess the serum cystatin C as an early marker of diabetic nephropathy. Aim: To measure the serum cystatin C levels in T2DM patients with normoalbuminuria, microalbuminuria and macroalbuminuria. Materials and Methods: 90 known T2DM patients in the age group of 40-70 years were selected and further categorized according to the urine albumin-creatinine ratio into normoalbuminuria, microalbuminuria and acroalbuminuria, with 30 patients in each group. Height, weight, BMI and serum cystatin C were measured. Results: Mean of cystatin C was 0.94+0.23, 1.11+0.25 and 1.64+0.68 mg/L for the three groups respectively. In group A, group B and group C, the normal cystatin C levels were 70%, 56.7% and 20% respectively. Conclusion: Cystatin C is more sensitive, possibly a better marker for detection of early renal impairment in T2DM.
Authors and Affiliations
S Sindu Priya, S Uma Maheswari
Keywords
Related Articles
- EP ID EP410266
- DOI -
- Views 167
- Downloads 0
A comparative community based cross-sectional study of lipid profile among healthy urban and rural local ethnic Mising population in a district of upper Assam
Background: Abnormalities in lipid profile are important risk factors for cardiovascular disease. Ethnicity, cultural and socioeconomic characteristics influence the lipid profile in different populations. Mising ethnic...
Lipid profile patterns in university students
Background: Early detection of lipid imbalance should begin in adolescence in order to focus on long-term prevention of atherosclerosis by controlling the risk factors. Aim: The present study was, designed to study lipid...
The study of C reactive protein, plasma fibrinogen, urinary albumin creatinine ratio and superoxide dismutase as biomarkers in hypertension
Objective: To study four biomarkers from distinct biological pathways that lead to hypertension, namely high sensitivity C reactive protein (hs CRP), fibrinogen, urinary albumin Creatinine ratio(UACR) and superoxide dism...
Serum uric acid and urinary albumin in patients of type II diabetes mellitus
Diabetes mellitus has been known to be a state of oxidative stress with excess generation of free radicals contributed by several mechanisms including hyperglycemia. Uric Acid is the final oxidation product of purine met...
The biochemical assessment of coronary artery disease in patients of mental depression
Problem Statement: Mental depression as such though a social problem but its complications share a good number of morbidity and mortality. Various reports have suggested that mental depression can lead to coronary artery...