Serum adenosine deaminase levels in patients with type 2 diabetes mellitus and its relation with fasting blood glucose and glycated hemoglobin levels
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Background: Insulin resistance and decreased insulin secretion are the main physiological abnormalities of Type 2 Diabetes Mellitus (DM). Cell mediated immune system disturbance and improper T lymphocyte function also contribute to the pathophysiology of Type2 DM. Chronic hyperglycemia leads to increased oxidative stress and increases Adenosine deaminase(ADA) levels, Both these lead to insulin resistance. As there is relationship between cell mediated immunity, ADA and Type 2 DM, the present study was undertaken to determine S.ADA levels in Type 2 DM and highlight its importance in the immunopathogenesis of Type 2 DM. The study also aims to find correlation between S. ADA and Fasting Blood Sugar (FBS), Glycated hemoglobin (HbA1c). Materials and Methods: 100 individuals in the age group 35 to 65 yrs of established Type 2 DM were included in the study group. Study group is further divided into 2 groups Group I includes 50 Diabetics with HbA1c <7 % and Group II includes 50 Diabetics with HbA1C >7 %. A group of 50 Normal healthy age matched individuals served as the control group. In both groups FBS, S.ADA and HbA1C are measured and compared using Student T test and pearsons correlation statistics. Results: The study showed that FBS, S.ADA and HbA1c levels were significantly higher in group I and Group II when compared to control group. Comparison between group I (well controlled Diabetes patients) and Group II (poorly controlled Diabetes Patients) showed significantly increased ADA activity (p<0.001). There was positive correlation between ADA and HbA1c in groups I and II (p< 0.01 and p<0.001 respectively) Conclusions: Increased S.ADA activity may be an important indicator of immunopathogenesis of Type 2 DM and hence can serve as a marker for diagnosis of DM. Positive Correlation between S.ADA and HbA1c suggests that S. ADA levels can be used for assessing the short term and long term Glycemic status in Type 2 Diabetes Mellitus.
Authors and Affiliations
P Kiranmai
Keywords
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- EP ID EP486137
- DOI 10.26611/1002537
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