Role of 25 hydroxy Vitamin-D in parkinson’s disease
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 3, Issue 1
Abstract
Abstract Problem statement: Parkinson disease is the second most prevalent neurodegenerative disease worldwide. In the initial stage of the disease, the most obvious symptoms are movement related, which include tremors, rigidity, slowness of movement and difficulty with walking and gait. Behavioural problems and dementia also appears in advanced stage of the disease. Depression is the most common psychiatric symptom and often associated with emotional disorder and sleep disturbances. The disease is common in older and mostly occur after 50 years of age. Methods: It was observational, and case control study to find out that vitamin-D could be regarded as a predictive bio-marker for severity of Parkinson’s Disease. A direct interview of the eligible study participants were carried out treatment sheets were reviewed and after duly explaining the procedures in their local languages. Detailed records of demographic and clinical features were noted in case record proforma. History of name, age sex, religion occupation symptom, duration, history of recurrence etc. was recorded. Patients with PD attended in the Medicine OPD were selected as cases. Total sample size was 30. All subjects was above the age of 60 years The period of the study was one (01) Year beginning from2015 to2016. Results: All cases and control are age match α = 30. Control groups were selected from the community. Fasting glucose level of control and case where within biological reference intervals, mean control value 88.22 ± 13.9 mean case 100.45 ± 8.79. The result is statistically significant p value- <001. Serum Calcium levels of both case and control group are within biological reference interval. Mean value in PD 8.45, SD ± 2.21 and for control 8.83 SD ± 0.49, p Value – <0.3999. It was statistically not significant. Serum level of Vitamin-D in Parkinson Disease (16.51 ± 3.08) is lower in comparison to control group (25.92 ± 3.96) p Value- 0.000. The result was statistically significant control group are within insufficiency range (20 – 29 ng/ml). Conclusion: All patients of our study showed a deficient level (less than 20 ng/ml) of vitamin-D. The control group surprisingly had vitamin-D level in insufficient range (20 – 29 ng/ml). The reason for this insufficient level of Vitamin-D may be searched for in future with large number of sample size.
Authors and Affiliations
Yogesh Krishna Sahay, Madhu Sinha
Keywords
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