Atherogenic index of plasma in subclinical hypothyroidism
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 2
Abstract
Background: Subclinical Hypothyroidism (SCH) is increased thyrotropin-stimulating hormone(TSH) accompanied by normal T3 and T4 levels. SCH is associated with metabolic derangements, elevated cholesterol, increased incidence of atherosclerosis, leading to cardiovascular risk. Significance of dyslipidemia in SCH remains controversial. Many studies have involved various indices to detect cardiac events in SCH significant attention is focused on alternative biochemical markers to assess dyslipidemia. Aims and objectives: aim of present study was to assess lipid atherogenic risk based on Atherogenic index of plasma (AIP). Objective was to quantitatively detect levels of, HDL-Cholesterol, and triglycerides to evaluate the importance of AIP as better predictor of cardiovascular risk in SCH. Materials and Methods: 30 SCH cases compared with 30 euthyroid controls. Serum T3, T4, TSH estimated by ELISA method, Serum HDL-Cholesterol by enzymatic CHOD-PAP method, Triglycerides by GPO-POD method. Atherogenic index of plasma (AIP) log (TG/HDL-C) was calculated on all the samples. Results:: Serum levels of TSH(P<0.001), TC( p<0.001), HDL( p<0.001), LDL( p<0.001), AIP ( p<0.001),showed significant increase. No significant change in levels of serumT4 was observed. Conclusion: Results contribute to high atherogenic risk as indicated by AIP. So AIP can be used as better indicator of dyslipidemia as compared to isolated lipid profile parameters and highlights cardiovascular risk in SCH.
Authors and Affiliations
Smita Kottagi, Triveni Jambale, Srinivas Deshpande, Amareshwar Malagi
Keywords
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