Serum homocysteine as an independent risk factor in young patients of ischemic stroke
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 2
Abstract
Background: Abnormal Homocysteine (HCY) level appear to contribute to atherosclerosis by direct toxic effect that damages the arterial linings, interfering with the clotting factors and oxidation of LDL. Elevated homocysteine appears to be associated with an increased risk of the large artery subtype of ischemic stroke, and possibly to the small artery subtype. Objective: This case control study was designed to study the Homocysteine levels in young patients with Ischemic Stroke and to carry out statistical analysis to evaluate Homocysteine as an independent risk factor for Stroke. Methods: The mean serum Homocysteine in patients of Stroke and control was calculated and its association with Total cholesterol, LDL cholesterol and HDL cholesterol. Results: The mean serum Homocysteine in case and control was 28.14 µmol / L and 11.18 µmol / L respectively with S.D of 7.88 µmol / L and 1.82 µmol / L respectively with a significant p value of 0.0001. The difference in Homocysteine levels observed between patients with LDL-C ≥ 100 mg% and those with LDL-C < 100 mg% was not significant. The difference in Homocysteine levels observed between patients with HDL-C ≥ 40 mg% and those with HDL-C < 40 mg% was not significant. The difference in Homocysteine levels observed between patients with S. Cholesterol ≥ 200 mg% and those with S. Cholesterol < 200 mg% was not significant. Conclusion: From the above findings, in this study the low levels of LDL-C and high levels of HDL-C did notprotect the patients against the Homocysteine induced ischemic stroke. Also there was not significance found between high total cholesterol and Homocysteine induced stroke thereby making homocysteine as an independent risk factor for ischemic stroke
Authors and Affiliations
Asutosh P Chauhan
Keywords
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- EP ID EP442157
- DOI 10.26611/1002825
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