Urinary NGAL as an early marker of renal injury in Type II diabetics
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 3
Abstract
Background: Microalbuminuria is a reversible stage of renal dysfunction in Diabetic patients and it’s detection allows early intervention thus checking its progress to ESRD. However, Microalbuminuria is transient and may vary in conditions such as fever, post-exercise, ingestion of plenty of water, diuresis, during acute illnesses and immediately after any surgery. A reliable biomarker is required therefore to diagnose early, reversible stage of renal dysfunction. Recent studies have shown Urinary Neutrophil Gelatinase Associated Lipocalin (UNGAL) as a reliable marker of renal injury. Objective: Was to estimate UNGAL and to evaluate its utility in the prediction of tubular and glomerular injury in normoalbuminuric Type 2 Diabetics. Materials and Methods: 40 normoalbuminuric Diabetics, 20 Microalbuminuric Diabetics and 20 clinically healthy controls visiting the Ramaiah Medical Hospital were included in the study. Exclusion criteria for this study was pregnancy, hypertension, patients with diseases of heart, prostrate, GIT, respiratory system and liver, other renal diseases and those on nephrotoxic drugs. Ethical clearance was obtained from the Institutional Ethical Board. After obtaining consent from patients, serum glucose, serum creatinine, HbA1c, Urinary albumin, Urinary creatinine and UNGAL was estimated. Results and Conclusion: Urinary ACR and UNGAL on comparison between the groups showed a significant difference. UNGAL showed a significant rise in the normoalbuminuric group with a P-value of <0.001 in comparison with controls suggesting it can be used as early screening marker for renal injury even before they progress to microalbuminuric stage.
Authors and Affiliations
Pavana A, K C Vasudha, Pramila Karla
Keywords
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