Study of association between Hypothyroidism and kidney dysfunction
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 5, Issue 3
Abstract
Thyroid hormones have a significant impact on kidney health and disease. Thyroid hormones have pre-renal and intrinsic renal effects by which they increase the renal blood flow and Glomerular filtration rate. Several studies indicate that thyroid hormones directly influence normal growth, development and physiology of kidneys. Hypothyroidism is associated with reduced GFR, increased serum Creatinine and blood Urea levels indicating renal dysfunction with several molecular and hemodynamic factors regulated by thyroid hormones. The purpose of this study was to screen for renal disease in hypothyroid patients and to find association between kidney dysfunction and hypothyroidism. A study on RFT (serum creatinine and blood urea levels) in newly diagnosed 40 hypothyroidism patients attended OPD over a period of 4 months and 40 age and sex matched healthy controls was done. The statistical analysis of serum T3 (P<0.001), T4 (P<0.001), TSH (P<0.001), Urea (P<0.001) and serum creatinine (P<0.001) were highly significant indicating significant association between kidney dysfunction and thyroid profile. There is a consistent and reversible increase of serum creatinine and Urea levels in the hypothyroid state. Most of the renal anifestations of thyroid disorders, which are clinically most significant with Hypothyroidism, are reversible with treatment and this study needs further evaluation.
Authors and Affiliations
Sowjanya Yerram, Bhanupriya Tammineni
Keywords
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