Levels of sialic acid, lactate dehydrogenase and -glutamyl transferase in patients with carcinoma breast
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 6, Issue 1
Abstract
Background: Breast cancer is a malignant proliferation of epithelial cells lining the ducts or lobules of the breast. It is difficult to diagnose a patient in the early stages of the disease, therefore essential to develop investigations, which are cost effective and easy to perform at the primary care setup. The study is designed to assess the role of Sialic acid, Lactate dehydrogenase and γ-Glutamyl transferase in patients with carcinoma breast. Material and methods: This prospective randomised study was carried out on 60 female patients with carcinoma breast, divided into 3 groups. Levels of Sialic acid, Lactate dehydrogenase, γ-Glutamyl transferase were estimated in them, before and after treatment values are then compared with 90 controls. Results: The meanstandard deviation (SD) values of all the studied parameters were 420.2273.44 for sialic acid; 92.9855.94 for LDH and 37.3440.71 for GGT. The values compared with controls and p value found to be significant (<0.001). The sensitivity, specificity and diagnostic accuracy was also calculated. Discussion: We have found significantly elevated total protein bound sialic acid levels in patients of breast cancer,there is an up regulation of LDH in the malignant cells also in patients with metastasis along with the elevation of GGT levels. Conclusion: We concluded, significantly elevated sialic acid levels are found in patients compared to controls, with 100% sensitivity and specificity. LDH and GGT levels are significantly elevated in patients and can be used for early diagnosis, staging and also to monitor the response of disease to the treatment
Authors and Affiliations
M Gouri Devi, Mohammed Abdullah Saad, A V Rukmini, A Dhana Lakshmi, Rama Rao
Keywords
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