Protein bound hexose and protein bound hexosamine as diagnostic indicators in severe depression
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 3
Abstract
Background: Depressive illness is considered to be a psychoneuro-immunological disorder due to peripheral immune activation through the release of pro inflammatory cytokines. Cytokines enhance the hepatic synthesis of glycoproteins. Total glycoproteins are estimatied the protein bound hexose and protein bound hexosamine levels. Aim: To analyze whether protein bound hexose (PBH), protein bound hexosamine (PBHex) can be used as diagnostic indicator in severe depression. Material and Methods: The present study included 100 subjects which were grouped as Group I (Cases): included the patients who were diagnosed as having severe depression diagnosed on the basis of ICD –10 criteria. Group II (Controls): Healthy control subjects were selected from volunteers. Serum levels of protein bound hexose (PBH), protein bound hexosamine (PBHex) were estimated. Results: The mean level of Protein bound Hexose in severe depression was 191.054.01 mg% whereas it was 102.505.81 mg% (p value <0.0001). The mean level of Protein bound Hexosamine in severe depression was 97.505.06 mg% whereas it was 78.504.97 mg% (p value <0.0001). The mean levels of Protein bound Hexose and Protein bound Hexosamine in severe depression was significantly higher than controls. (p value <0.0001). Conclusion: The present study shows significantly increased levels of protein bound hexose and hexosamine in severe depressive patients. As serum glycoproteins are non-specific indicators of severe depression, they cannot be used as a diagnostic marker.
Authors and Affiliations
N Dheebalakshmi, S UmaMaheswari
Keywords
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- EP ID EP521737
- DOI 10.26611/1002934
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