Correlation between serum PON-1 activity and lipid profile in diabetes mellitus
Journal Title: Medpulse International Journal of Biochemistry - Year 2018, Vol 8, Issue 2
Abstract
Background: PON1 has detoxification activity in atherosclerotic processes. Serum PON1 activity has been shown to be reduced in atherogenesis. Thus, estimation of PON activity in diabetes mellitus is being valuable in predicting atherosclerosis and future cardiovascular events. Aim: To correlateserum PON-1 activity and lipid profile in diabetes mellitus. Material and Methods: A total of 100 subjects were selected and were grouped into: Control group (50 healthy individuals) and Study group (50 patients with diabetes mellitus).Serum PON-1 activity and serum Glucose, Total cholesterol and HDL cholesterol were estimated. Results: Mean values of HDL in study group (35.28 ± 3.8) was significantly decreased than that of control group (44.24 ± 2.12). (P= <0.0001). Comparison of mean values of lipid profile levels in control group showed a significant increase of all the above parameters in the study group (p= <0.0001). Conclusion: A significant decrease in PON-1 activity was observed in DM patients. The levels of HDL shows a significant positive correlation with the PON activity. Thus, PON-1 activity may act as a useful marker for early prediction of atherosclerosis in DM.
Authors and Affiliations
Ramadevi M, Sumathi .
Keywords
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- EP ID EP442139
- DOI 10.26611/1002823
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