Study of role of serum LDH in carcinoma of breast as a prognostic biomarker
Journal Title: Medpulse International Journal of Biochemistry - Year 2019, Vol 9, Issue 1
Abstract
Background: Carcinoma breast is commonest cancer in urban and rural females in India. Presently, India already has one of the worst survivals from breast cancer, in the world. Cancer is a group of diseases that cause cells in the body to change and grow out of control. While considering the strategy of treatment, accurate estimation of prognosis in breast cancer is very important. Diagnosis at advanced stages of disease contributes to the high mortality rate among women due to breast cancer. There is no way we can prevent breast cancer, but we can definitely detect it early and treat adequately. There is need for simple biochemical investigations which can be easily assayed and are less expensive. Materials and Methods: The present cross-sectional analytical study was conducted in department of biochemistry in collaboration with surgery department. Total of 200 subjects of 25-75 age group were included in the study out of which 100 were cases of breast cancer and 100 age and sex matched healthy controls. Serum levels of LDH were estimated in all subjects. Result: The present study shows that there was statistically significant increase in serum LDH in cases compared to controls. Conclusion: Serum LDH levels were found to be higher in breast cancer cases than controls which may serve as biomarker in carcinoma breast. It may help in assessing progression of the disease. It can be easily assayed in laboratories.
Authors and Affiliations
Megha Ganesh Bangar, Neelam Jayant Patil, Sharmila Mane
Keywords
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- EP ID EP485900
- DOI 10.26611/1002913
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