A STUDY ON HAEMATOLOGICAL ABNORMALITIES IN DECOMPENSATED CHRONIC LIVER DISEASE
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2017, Vol 4, Issue 35
Abstract
BACKGROUND Liver plays an important role in normal erythropoiesis and synthesis of clotting factors. Chronic liver disease (CLD) patients are frequently associated with abnormalities in haematological parameters. MATERIALS AND METHODS This was an observational study conducted among diagnosed CLD patients over a period of 1 year from 2013 to 2014. Various haematological abnormalities in 75 CLD patients were studied. Relevant details were obtained in structured format. RESULTS The mean age of the study group 49.2 years. Male-to-female ratio was 5.8:1. Aetiologies of cirrhosis were alcoholism (61.3%), diabetes mellitus (26.7%) and dyslipidaemia (13%). 88% patients were anaemic with severe anaemia (Hb <8 gm%) observed in 33.3% patients with mean Hb being 8.76 gm%. Mean Hb in alcohol-related CLDs were lower than CLDs due to other aetiologies (8.62 gm% vs. 9.36 gm%). Most common anaemia observed was normocytic normochromic anaemia (40.9%). 26.7% had leucopenia and 88% had thrombocytopenia. Normal ferritin levels were observed in 6.7%, decreased in 16% and increased in the remaining cases of which a level of more than 900 ng/mL was observed in 18.7% cases. Mean CTP (ChildTurcotte-Pugh) score of the study group was 11.1. 80% of patients belong to child C. Patients with high ferritin levels had high CTP score (P-0.001). Platelet count decreases as CTP score increases (P-0.000) and as spleen size increases (P-0.001). CONCLUSION Most common haematological abnormalities observed were thrombocytopenia and anaemia. Severe anaemia was seen in males and alcoholics. Thrombocytopenia was more in those with advanced liver disease and large spleen. High serum ferritin level correlate well with advanced liver disease.
Authors and Affiliations
Suresh Moothezhathu Kesavadas, Santhosh Kumar Thulaseedharan Saraswathy, Muhammed Muhammed
Keywords
Related Articles
- EP ID EP218863
- DOI 10.18410/jebmh/2017/408
- Views 124
- Downloads 0
STUDY OF CLINICAL PROFILE IN NEONATES AFFECTED BY HIGH ENVIRONMENTAL TEMPERATURE DURING SUMMER MONTHS 2016
BACKGROUND Definite data on effect of heat in neonate is not documented, although there are numerous studies and evidences on hypothermia in neonates. The aim of the study is to study the1. Clinical and biochemical profi...
THE STUDY OF MICRONUCLUES INDEX IN PATIENTS PRESENTING WITH MALIGNANT LESIONS
Micronucleus is the nucleus that expresses the genotypic alterations caused in the process of malignancy. It is characteristically seen in exfoliated epithelial cells like Buccal Mucosa and urinary bladder wall during pr...
MANAGEMENT OF PSEUDOARTHROSIS OF SHAFT HUMERUS BY PLATING (FIVE YEARS FOLLOW UP) – A CASE STUDY
Pseudoarthrosis is a condition where union at fracture site is very difficult to obtain. But sticking to the very basic principles of management of non-union – that is freshening at fracture site, removal of sclerotic bo...
TO STUDY THE DENTAL CONDITIONS IN DIABETES MELLITUS PATIENTS
BACKGROUND Periodontal disease is a chronic inflammatory condition and is now considered as the sixth complication of diabetes and also one of the major oral complications of diabetes mellitus. Oral health is associated...
A COMPARATIVE STUDY OF PREOPERATIVE DIAGNOSIS AND PATHOLOGICAL DIAGNOSIS IN ADRENAL SWELLINGS
BACKGROUND The adrenal gland neoplasms include primary and metastatic malignant tumours. They can be functional or non-functional and also detected as incidentaloma lesions. Advanced imaging often reveals adrenal tumours...