A Study on Haemodynamic and Adverse Effects of Intramuscular Parecoxib in Adults for Postoperative Pain Relief
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2017, Vol 4, Issue 4
Abstract
Background: Postoperative pain control is generally best managed by anaesthesiologists since they offer regional anaesthetic techniques as well as pharmacological expertise in analgesics.Various postoperative analgesic modalities are offered in day to day practise such as oral or parenteral analgesics, peripheral nerve blocks, neuraxial blocks with local anaesthetics, intraspinalopioids TENS and others. Use of traditional NSAIDs have many side effects like gastritis, pepticulceration, bleeding from upper G I tract, delayed platelet inhibition, headache, vertigo, insomnia, bronchospasm, allergic reaction, anaemia, nephrotoxicity, salt and water retention.In contrast to NSAIDs, cox2 inhibitors like Parecoxib are free from adverse effects and drug dependence.Hence we thought it is appropriate to study the haemodynamic and adverse effects of intramuscular Parecoxib for post operative pain relief. Materials and Methods: This study comprised of 100 postoperative patients of both sexes betweenage group of 1870 years who were scheduled for various elective surgical proceduresand all thosewho satisfied inclusion and exclusion criteria. All patients are visited preoperatively; written consent was taken and premedicated with diazepam 0.2 mg/kg body weight at night. Parecoxib sodium 40 mg given in the recovery room, when patient complained of pain. Heart rate and blood pressure were recorded at intervals. Adverse effects were noted. The observation were recorded, tabulated and subjected to statistical analysis. Results: In the study group, 45 were males and 55 were females. There was no significant change in blood pressure or heart rate for 28 hours after intramuscular administration. There were 9% of patients with nausea and vomiting, 4% with headache and 3% with pruritus. Conclusion: Intramuscular Parecoxib provides good postoperative analgesia with no haemodynamic variations and minimal adverse effects.
Authors and Affiliations
Geetanjali S. Masamaddi
Keywords
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- EP ID EP472296
- DOI 10.21088/ijaa.2349.8471.4417.11
- Views 80
- Downloads 0
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