A Study on Importance of Molecular Subtyping As a Prognostic Indicator of Breast Carcinoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
BACKGROUND: Breast cancer (BC) is no longer seen as single disease but rather multifaceted disease comprised of distinct biological subtypes with diverse natural history. Molecular subtyping of Breast Cancer helps in prediction of disease outcome and therapy. METHODS: 82 patients with IDC type BC, from January ,2014 to August, 2018 in IPGME&R, Kolkata were taken in this study group. Receptors status analyzed by Immuno-histochemistry study and correlated with clinico-pathological parameters, OS and DFS studied on follow up. Exposure to different risk factors also assessed. RESULT: Most of the patients in this study were between 51-60 yrs of age. Triple negative subtype was most prevalent as compared to other subtypes. Disease free survival (DFS) was best in Lumina B (80%) followed by Luminal A (77.85). Her2 neu group had highest recurrence rate (23%), comparable with Triple negative groups (15.2%). Overall survival was best among Luminal A (94.4%). CONCLUSION: . Luminal B and LuminalA subtypes showed good DFS and OS as compared to Her2 neu and Triple negative subtypes.
Authors and Affiliations
Dr Anirban Das, Dr Chiranjit Mukherjee, Dr Arnab Chakraborty, Dr Amit Kumar Das
Keywords
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- EP ID EP439954
- DOI 10.9790/0853-1801101015.
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