A Study on N-terminal-pro Brain-type Natriuretic Peptide in Cirrhosis of Liver
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 4
Abstract
Background: Plasma N-terminal-pro brain-type natriuretic peptide (NT-proBNP) is a standard test for detection of heart failure. There is a conjecture that progressive heart failure occurs in cirrhosis of liver. This study is undertaken to investigate the plasma concentrations of NT-proBNP in a case of cirrhosis of liver. Methods: 35 patients with pre-diagnosed cirrhosis of liver were divided into three groups according to the Child-Pugh classification: Grade A (n=11, 32%), B (n=12, 34%), and C (n=12, 34%). Blood pressure, electrocardiogram, and echocardiography were done in all these patients. Plasma NT-proBNP levels were determined in all these patients using an electrochemiluminiscence sandwich immunoassay technique. Results: The presence of heart failure (diagnosed clinically, left ventricular ejection fraction <50% and higher serum NT-proBNP level, with a cutoff value of >101 pg/mL) was correlated with degrees of severity of cirrhosis of liver according to Child-Pugh scoring (sensitivity, 87.60% and specificity, 72.73%; P < 0.001). Conclusions: NT-proBNP which is a marker of the presence of heart failure was significantly correlated with progression of liver cirrhosis. In cirrhotic patients, high NT-proBNP value >101 pg/mL was shown to be a valuable non-invasive parameter in predicting the presence of heart failure. Therefore, serial measurements of NT-proBNP can be used in cirrhosis of liver for early detection of heart failure.
Authors and Affiliations
Palash Kumar Sanyal, Arup Bandyopadhyay
Keywords
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