A STUDY ON PAPILLARY THYROID CARCINOMA- HISTOPATHOLOGICAL VARIANTS AND PATTERNS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 19
Abstract
BACKGROUND Papillary carcinoma is a frequently reported thyroid malignancy. Diagnosis is based on the microscopic architecture and the characteristic nuclear features such as nuclear clearing, grooves and pseudo inclusions which can be seen on routine haematoxylin and eosin stained sections. Many morphological variants of this entity have been reported in the literature, classical papillary thyroid carcinoma (PTC) being the most common variant. Follicular, solid, tall cell, columnar etc., are the other variants. Some of these variants cause diagnostic difficulties on histopathological examination and also they have varied prognostic implications. METHODS This is a retrospective descriptive study which included 44 cases of papillary thyroid carcinoma diagnosed on histopathology over a period of 3 years. RESULTS Classical PTC was the most common variant (52.3%), followed by papillary micro carcinoma (13.6%), follicular variant (11.4%), mixed type that had features of both papillary and follicular (9.1%), tall cell and solid variants (4.5% each); and encapsulated, Warthin-like variants (2.3% each). Associated Hashimoto’s thyroiditis was seen in 20.4% cases (n=9/44). CONCLUSIONS Papillary thyroid carcinomas showed a female sex predilection. Though seen within a wide age range, they were more common in the third decade. Classical papillary thyroid carcinoma was the most common variant followed by micro papillary carcinoma and follicular carcinoma. Rare variants found in the study were tall cell and Warthin like variants. Nodular goitre and Hashimoto thyroiditis were the common lesions associated with PTC. Histological variations and patterns in papillary thyroid carcinoma have prognostic implications, so it is important to identify and report them whenever present.
Authors and Affiliations
Parasa Gayatri Devi, Mark Ruth Prasanna, Turlapati Satya Prakash Venkatachalam
Keywords
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- DOI 10.14260/jemds/2019/339
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