A Study on Serum Amylase Levels in Acute Organophoshorous Poisoning and It’s Relationship with Clinical Severity And Outcome
Journal Title: GJRA-Global Journal For Research Analysis - Year 2015, Vol 4, Issue 6
Abstract
Background & Objectives: Acute poisoning by organophosphorous Pesticides (OP) has reached epidemic proportions in most parts of the world, particularly in developing agrarian countries, where the toxicity of available poisons and paucity of appropriate medical facilities ensure a high fatality rate. Earlier, plasma cholinesterase was used to assess the severity of poisoning and determine the clinical course. Presently serum amylase has been recommended as a better indicator of severity. Hence in this study correlation between serum amylase levels and clinical severity of acute OP compound poisoning has been studied. Methods: A prospective study was conducted on 50 patients admitted to emergency ward within 24 hours of OP intoxication in Mamata Genereal Hospital, Khammam who met the inclusion criteria. Estimation of serum amylase was done at the time of admission and at 24 hours. The data was compared with 50 age matched individuals. Results: This study revealed significant elevation of serum amylase levels at admission in OP poisoning patients which showed significant decrease with treatment. The overall mean value for amylase was (174.26 in cases U/L Vs 32.08 in controls, p<0.0001) at admission. The bad prognostic factors are very well correlated with serum amylase levels are Fasciculations-311 U/L, Severe secretions-333 U/L, CNS depession-340 U/L, Respiratory failure-368 U/L and Convulsions-441 U/L. The overall mean value of serum amylase is significantly higher in non-survivors Vs survivors (318.4 U/L Vs 75.87 U/L, p<0.0001). Conclusion: Hyperamylasemia in OP intoxicated patients can provide a high degree of suspicion of subsequent respiratory failure and other complications.
Authors and Affiliations
Dr. Dilip M Rampure, Dr. I. B. Ganiger, Dr. CH. Ellareddy
Keywords
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