A STUDY ON STAT6 EXPRESSION IN SOLITARY FIBROUS TUMOUR
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 45
Abstract
BACKGROUND Solitary Fibrous Tumour (SFT) is an uncommon mesenchymal neoplasm of fibroblastic type arising anywhere in the body. Classic SFTs show neoplastic cells arranged in a pattern of less architecture with alternating hypo and hypercellular areas and prominent branching vasculature. Traditionally, CD-34 expression is the most consistent finding in SFTs, however this expression is also common in other tumours that may mimic SFT. Recently, a recurrent gene fusion NAB2-STAT6 has been identified as molecular hallmark of SFT. Molecular detection of the fusion gene and immunohistochemical expression of nuclear STAT6 can be helpful in diagnosing SFT. Aim- To study the expression of STAT6 in SFT. MATERIALS AND METHODS 23 cases of SFT diagnosed during a 2-year period. STAT6 immunohistochemistry was performed on 18 SFT cases and also on 8 possible mimickers of SFT, which were taken as the (negative) control. RESULTS Nuclear STAT6 positivity was present in 18/18 (100%) cases of SFT, which were usually diffuse (4+ in 16 cases, 3+ in 1 case and 1+ in 1 case and intensity was strong in 15 cases, moderate in 2 cases and weak in 1 case). All other tumour types tested were negative for STAT6. CD-34 was done in all cases at initial diagnosis. 16/18 cases (88%) were CD-34 positive. 2 cases (12%) which were CD-34 negative were STAT6 positive. CD-99 and Bcl-2 were positive in most of the cases. CONCLUSION Strong nuclear STAT6 expression is largely specific for SFT and is helpful in distinguishing it from histologic mimics.
Authors and Affiliations
Krishna Govindan, Nithya Jayakumar
Keywords
Related Articles
- EP ID EP549343
- DOI 10.14260/jemds/2018/1086
- Views 60
- Downloads 0
PROFILE OF BACTERIAL ISOLATES IN NEONATAL BLOOD CULTURE AND THEIR ANTIBIOTIC SUSCEPTIBILITY PATTERNS (ANTIBIOGRAM) IN NEONATAL SEPSIS AT A TERTIARY CARE HOSPITAL NICU IN SOUTH INDIA
BACKGROUND Neonatal sepsis is one of the major causes of morbidity and mortality in neonates. The spectrum of bacterial pathogens causes Neonatal sepsis and their antibiotic sensitivity patterns vary from hospital to hos...
EVALUATION OF PRACTICE PATTERN OF VTE PROPHYLAXIS IN POSTOPERATIVE PATIENTS
Venous thromboembolism (VTE) is one of the common complications in surgical patients. Venous thromboembolism (VTE), which is manifested as deep vein thrombosis (DVT) and pulmonary embolism (PE), represents...
DEXMEDETOMIDINE: AN IDEAL DRUG FOR PROCEDURAL SEDATION OUTSIDE OPERATION THEATRE
Procedural sedation and analgesia (PSA) is a method of administering sedatives or dissociative agents to patients undergoing unpleasant procedures. It has become the international standard of care for managing...
A COMPARATIVE STUDY OF CLINICAL CHARACTERISTICS AND BACTERIOLOGICAL SENSITIVITY PATTERN OF SPUTUM IN ACUTE EXACERBATIONS OF COPD
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) is an important cause of disability and death globally and scenario has worsened. Acute Exacerbation of COPD (AECOPD) is associated with airway inflammation resulti...
STUDY OF SERUM PROTEIN, ALBUMIN, GLOBULIN AND ALBUMIN/GLOBULIN RATIO IN RELATION WITH HIV PATIENTS
BACKGROUND Human Immunodeficiency Virus Infection (HIV) is gradually becoming a threat to our society. It affects our immune system. Proteins are important components of immune system. Notably albumin and globulin are ch...