A Study on the Pattern of Genetic Inheritance of Polycystic Ovarian Syndrome
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 10
Abstract
Aims: Inheritance of polycystic ovary syndrome (PCOS) is still a controversy. Our study aims to analyze the family history of PCOS features and related metabolic disturbances including the male members to determine the mode of their inheritance. Study Design: A cross sectional study with convenient sampling. Place and Duration of Study: Department of Medicine, Kasturba Medical College, Mangalore between 2009 and 2012. Methodology: Demographic data such as body weight and age was recorded. Menstrual, obstetric and medical history of 85 PCOS females was collected. Presence of metabolic syndrome (MetS) was confirmed. Blood pressure and waist circumference were measured. Biochemical and hormonal estimations were done. Relevant information required for the study of 604 members of first and second generation relatives was collected. SPSS (version 17.0) was used to analyze the data. Results: Seventy eight percent of the PCOS patients were either overweight or obese and 98% of them had hirsutism. Approximately, 33% of them had MetS which was higher in the first generation (62%) of PCOS relatives. An equal transmission of MetS characteristics from the paternal and maternal side indicated that it was not X- linked inheritance. Segregation analysis of nine families PCOS of patients suggested that MetS inheritance was autosomal dominant although PCOS inheritance was not. Conclusion: PCOS daughters come from families of MetS suggesting that parental MetS features may be related to the occurrence of PCOS in their off-springs.
Authors and Affiliations
Krithika D. Muralidhara, Prabha M. Adhikari, D. V. Muralidhara
Keywords
Related Articles
- EP ID EP347148
- DOI 10.9734/BJMMR/2015/13461
- Views 42
- Downloads 0
The Family Influence on the Gestational Age at Booking among Pregnant Women in Ogbomoso, Nigeria
Introduction: Family plays an important role in health seeking behaviour and education of its members. Educating an individual especially a girl child usually results in improvements in the quality of life because women...
Factors Associated with Drug Counterfeit in Nigeria: A Twelve Year Review
Background: Drug counterfeiting poses a great danger to every society. The actual prevalence of counterfeit drugs is difficult to ascertain presently but just like other crimes, drug counterfeiting is an underground busi...
Integrated Quiz Competition: A Innovative Method of Teaching and Learning in Undergraduate First Year Medical Course at RAKMHSU, UAE
Objectives: The main objective of this innovative active learning approach was to increase student’s interest in basic science subjects and to enhance student participation in acquiring the knowledge in the core and appl...
Assessment of Anti-inflammatory and Anti-nociceptive Properties of Aqueous Seed Extract of Carica papaya in Albino Wistar Rats
This study was undertaken to assess analgesic and anti-inflammatory properties of seed extract of Carica papaya. Aqueous extracts of the plant at doses of 100, 200, and 300 mg/kg body weight were used for the study on fi...
The Role of Twist1 in Stem Cell Differentiation through Mechanical Cues: A Review and Hypothesis
Due to the pivotal role of stem cell differentiation in regeneration and disease cure, the study of it has always been a research highlight during the recent years. Stress microenvironment has a great impact on cell grow...