A Study to Evaluate and Compare the Analgesic Efficacy of Transdermal Patch of Buprenorphine and Diclofenac in Osteoarthritis Knee
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: We studied the effects of transdermal patch of Buprenorphine and Diclofenac in patients of osteoarthritis(OA) knee. Material and methods: The present prospective, randomized single blind study conducted in the Dept. of Anaesthesiology PGIMS, Rohtak. A total of 50 patients of either sex and age (40years and above) enrolled for 1 month.Ethical clearance taken prior to study. Written informed consent taken for study. Patients randomly divided in 2 groups (B and D) of 25 each. Group B: Buprenorphine patch, received per week 10μg-hrGroup D: Diclofenac sodium patch, received per day 200 mg Diclofenac. Patch applied on dry, non-hairy of skin after cleaning the skin with spirit swab. The replacement patch applied to a different area of skin.Buprenorphine patch replaced once a week and Diclofenac patch replaced on daily basis. Paracetamol 500mg orally as a rescue analgesia. Results: Results obtained were statically comparable in both groups B and group D regarding Pain score (NRS), WOMAC index, Stiffness subscale score of WOMAC. Patient satisfaction were statistcally comparable in both groups. Results were clinically better in group D as compare to group B. The side effects noted were minimal in both groups B and group D and easily manageable statically comparable in both groups B and group D. Conclusion: This randomised,blind controlled study suggests that the Diclofenac and Buprenorphine patch is an effective and safe treatment modality for symptomatic OA of the knee and were well tolerated.This method is convenient and easy to use with no procedural complications. Diclofenac is slightly better tolerable and has better pain relief as compared to Buprenorphine.
Authors and Affiliations
Rajmala Jaiswal, Naresh Kumar, Geeta Ahlawat, Vineet Kumar, Teena Bansal, Jyoti Khanna
Keywords
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