A Study to Evaluate the Role of Dihydrotestosterone in the Pathogenesis of Benign Hyperplasia of Prostate and Prostatic Carcinoma in Patients Attending a Tertiary Care Hospital in Eastern India
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Benign hyperplasia of prostate and prostatic carcinoma are two important diseases of aging male with very high incidence rate. Androgens have been implicated in the pathogenesis of both BHP and Ca prostate. Dihydrotestosterone (the 5-α reduced derivative of Testosterone) is the major metabolite of testosterone in prostate. So DHT is thought to play an important role in the development and progression of both the diseases. The present study was aimed at assessing the inter-relationship between the tissue level of 5α-dihydrotestosterone and pathogenesis of benign hyperplasia of prostate and prostatic carcinoma. The tissue level of DHT has been estimated in transition zone and peripheral zone of prostate in BHP and Ca prostate patients the comparative analysis of the above parameters suggests that, 5α-DHT is implicated in the pathogenesis of BHP and Ca prostate in a zone-wise manner. The findings of the present study also reveal that, prostatic tissue level of 5α-DHT may be explored as a possible marker for the diagnosis of benign hyperplasia of prostate and prostatic carcinoma.
Authors and Affiliations
Sharmistha Chatterjee
Keywords
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